Michel Arrignon started studying at the Conservatoire National Supérieur de Musique de Paris at the age of 16 and won a first price for clarinet and for chamber music (Delécluse, Oubradous) at the age of 18. After completing an advanced course in chamber music, he left France to study in the United States (Forrest).
At the age of 19, Michel Arrignon played with the Orchestre Mondial des Jeunesses Musicales conducted by Eric Leindsdorf. He won a second price at the Geneva Concours International d'Exécution Musicale at the age of 24. He felt drawn to 20th century music and played with ensembles such as Musique Vivante (D. Masson) and 2E2M (P. Mefano). During the same year he was appointed teacher at the Orleans Conservatory.

Working with P. Boulez in the creation of the Ensemble Intercontemporain, he played the full 20th century repertoire and made several recordings with Boulez. During this time, Michel Arrignon played the debut performances of numerous works for clarinet including L. Berio Sequenza VIII, Ph. Féneton's Latitudes, G. Grisey piece for clarinet and trombone and K. Stockhausen's Donnerstag aus Licht.

After spending seven years with the ensemble Intercontemporain, Michel Arrignon joined the Orchestre National de l'Opéra de Paris as solo clarinetist. He has played with world famous musicians, he belongs to the M. Bourgue wind ensemble and he founded the O. Messian Quartet.

Michel Arrignon has been clarinet teacher at the Conservatoire National Supérieur de Musique de Paris since 1989. He devotes himself to teaching and to his career as an international soloist which includes concerts, master classes and sitting on the juries of international competitions. 
He has been the clarinet teacher at the Superior School of Music "Reina Sofia" in Madrid since 2009.

He is also clarinet consultant/tester for Buffet Crampon and is contributing to the development of the instrument since 1985.

Among his recordings, remarkable pieces such as pieces for solo clarinet by J.M. Singier and P. Burgan Webers concerto in Eminor, J. Molter's concerto in A for D clarinet, I. Stravinsky's Ebony concerto (EIC P. Boulez), 2 interpretations of W.A. Mozart concerto, one with the Orchestre de l'Opéra de Paris and G. Prêtre, the other with the Orchestre J.F. Paillard, in the original version for basset clarinet.